Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22975862 | 1.00 | MCL1 (0.82) | MCL1BCL2L11 | |
| SCHEMBL22975772 | 1.00 | MCL1 (0.82) | MCL1BCL2L11 | |
| SCHEMBL22975936 | 0.92 | MCL1 (0.76) | MCL1BCL2L11 | |
| SCHEMBL22975914 | 0.92 | MCL1 (0.76) | MCL1BCL2L11 | |
| SCHEMBL22975961 | 0.92 | MCL1 (0.76) | MCL1BCL2L11 | |
| SCHEMBL22975912 | 0.92 | MCL1 (0.76) | MCL1BCL2L11 | |
| SCHEMBL22975937 | 0.92 | MCL1 (0.76) | MCL1BCL2L11 | |
| SCHEMBL21344094 | 0.92 | MCL1 (0.76) | MCL1BCL2L11 | |
| SCHEMBL22976024 | 0.92 | MCL1 (0.76) | MCL1BCL2L11 | |
| SCHEMBL22975959 | 0.92 | MCL1 (0.76) | MCL1BCL2L11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3762393-B1 | ALPHA-HYDROXY PHENYLACETIC ACID PHARMACOPHORE OR BIOISOSTERE MCL-1 PROTEIN ANTAGONISTS | AMGEN INC (US) | 2023-01-11 | — | — | EP | disclosed |
| US-20210047344-A1 | ALPHA-HYDROXY PHENYLACETIC ACID PHARMACOPHORE OR BIOISOSTERE MCL-1 PROTEIN ANTAGONISTS | AMGEN INC. (US) | 2021-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210047344-A1 | ALPHA-HYDROXY PHENYLACETIC ACID PHARMACOPHORE OR BIOISOSTERE MCL-1 PROTEIN ANTAGONISTS | MCL1, BCL2A1, BCLAF1 | MCL1 1/4885BCL2L11 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.