SCHEMBL22976580

SCHEMBL22976580

CC1(N)CCN(c2c(C(=O)NC34CC(C3)C4)cnc(Cl)c2-c2cc(F)cc(F)c2)C1

nearest known ligand 0.39

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ PTPN11 Q06124 8/20 0.39
▸ CNR2 P34972 3/20 0.35
▸ CNR1 P21554 2/20 0.35
▸ SCN9A Q15858 1/20 0.35
▸ PIK3C3 Q8NEB9 2/20 0.34
▸ PIM2 Q9P1W9 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29720115 1.00 PTPN11 (0.39) PTPN11CNR2CNR1SCN9APIK3C3
SCHEMBL22976579 1.00 PTPN11 (0.39) PTPN11CNR2CNR1SCN9APIK3C3
Trifluoroacetic Acid SCHEMBL29720121 0.95 PTPN11 (0.36) PTPN11CNR2CNR1SCN9APIK3C3
Trifluoroacetic Acid SCHEMBL22976730 0.95 PTPN11 (0.36) PTPN11CNR2CNR1SCN9APIK3C3
SCHEMBL22976472 0.91 PTPN11 (0.37) PTPN11CNR2CNR1PIK3C3
SCHEMBL29720133 0.91 PTPN11 (0.37) PTPN11CNR2CNR1PIK3C3
SCHEMBL22976203 0.91 PTPN11 (0.37) PTPN11CNR2CNR1PIK3C3
SCHEMBL22976551 0.89 PTPN11 (0.35) PTPN11CNR2CNR1PIK3C3
SCHEMBL22976156 0.88 PTPN11 (0.35) PTPN11CNR2CNR1PIK3C3
Hydrochloric Acid SCHEMBL28777538 0.88 PTPN11 (0.35) PTPN11CNR2CNR1PIK3C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12600709-B2 Nonpeptide somatostatin type 5 receptor agonists and uses thereof Crinetics Pharmaceuticals, Inc. (US) 2026-04-14 — — US disclosed
US-20250136573-A1 NONPEPTIDE SOMATOSTATIN TYPE 5 RECEPTOR AGONISTS AND USES THEREOF Crinetics Pharmaceuticals, Inc. 2025-05-01 — — US disclosed
US-11479540-B2 Nonpeptide somatostatin type 5 receptor agonists and uses thereof Crinetics Pharmaceuticals, Inc. (US) 2022-10-25 — — US disclosed
EP-4013748-A1 NONPEPTIDE SOMATOSTATIN TYPE 5 RECEPTOR AGONISTS AND USES THEREOF Crinetics Pharmaceuticals, Inc. (US) 2022-06-22 — — EP disclosed
CN-114585614-A Non-peptide somatostatin type 5 receptor agonists and uses thereof 克林提克斯医药股份有限公司 2022-06-03 — — CN disclosed
US-20220144802-A1 NONPEPTIDE SOMATOSTATIN TYPE 5 RECEPTOR AGONISTS AND USES THEREOF Crinetics Pharmaceuticals, Inc. 2022-05-12 — — US disclosed
WO-2021030262-A1 NONPEPTIDE SOMATOSTATIN TYPE 5 RECEPTOR AGONISTS AND USES THEREOF Crinetics Pharmaceuticals, Inc. (US) 2021-02-18 — — WO disclosed
US-20210047287-A1 NONPEPTIDE SOMATOSTATIN TYPE 5 RECEPTOR AGONISTS AND USES THEREOF Crinetics Pharmaceuticals, Inc. 2021-02-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220144802-A1 NONPEPTIDE SOMATOSTATIN TYPE 5 RECEPTOR AGONISTS AND USES THEREOF SSTR5, SSTR4, SSTR3 PTPN11 314/4885CNR2 289/4885CNR1 291/4885
US-11479540-B2 Nonpeptide somatostatin type 5 receptor agonists and uses thereof SSTR5, SSTR4, SSTR3 PTPN11 314/4885CNR2 289/4885CNR1 291/4885
US-20250136573-A1 NONPEPTIDE SOMATOSTATIN TYPE 5 RECEPTOR AGONISTS AND USES THEREOF SSTR5, SSTR4, SSTR3 PTPN11 314/4885CNR2 289/4885CNR1 291/4885
US-20210047287-A1 NONPEPTIDE SOMATOSTATIN TYPE 5 RECEPTOR AGONISTS AND USES THEREOF SSTR5, SSTR4, SSTR3 PTPN11 314/4885CNR2 289/4885CNR1 291/4885
US-12600709-B2 Nonpeptide somatostatin type 5 receptor agonists and uses thereof SSTR5, SSTR4, GLP1R PTPN11 492/4885CNR2 438/4885CNR1 413/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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