Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 16/20 | 0.45 |
| ▸ | CDK2 | P24941 | 16/20 | 0.45 |
| ▸ | CDK4 | P11802 | 13/20 | 0.45 |
| ▸ | CCND1 | P24385 | 13/20 | 0.45 |
| ▸ | CCND3 | P30281 | 13/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 13/20 | 0.45 |
| ▸ | CDK1 | P06493 | 12/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 12/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.45 |
| ▸ | CDK9 | P50750 | 6/20 | 0.45 |
| ▸ | CDK7 | P50613 | 6/20 | 0.45 |
| ▸ | CCNH | P51946 | 6/20 | 0.45 |
| ▸ | MNAT1 | P51948 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CCNK | O75909 | 1/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22977439 | 0.90 | CCNE1 (0.54) | CCNE1CDK2CDK4CCND1CCND3 | |
| SCHEMBL22977500 | 0.89 | CCNE1 (0.55) | CCNE1CDK2CDK4CCND1CCND3 | |
| SCHEMBL22977255 | 0.81 | CCNE1 (0.41) | CCNE1CDK2CDK4CCND1CCND3 | |
| SCHEMBL22977285 | 0.80 | CCNE1 (0.40) | CCNE1CDK2CDK4CCND1CCND3 | |
| SCHEMBL22976957 | 0.80 | CCNE1 (0.55) | CCNE1CDK2CDK4CCND1CCND3 | |
| SCHEMBL22977401 | 0.79 | CCNE1 (0.66) | CCNE1CDK2CDK4CCND1CCND3 | |
| SCHEMBL29821066 | 0.78 | CDK4 (0.42) | CCNE1CDK2CDK4CCND1CCND3 | |
| SCHEMBL22977497 | 0.77 | CCNE1 (0.44) | CCNE1CDK2CCNT1CDK9CDK7 | |
| SCHEMBL22977442 | 0.75 | CCNE1 (0.55) | CCNE1CDK2CDK4CCND1CCND3 | |
| SCHEMBL22977089 | 0.74 | CCNE1 (0.57) | CCNE1CDK2CDK4CCND1CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11427567-B2 | Imidazolyl pyrimidinylamine compounds as CDK2 inhibitors | INCYTE CORPORATION (US) | 2022-08-30 | — | — | US | disclosed |
| US-20210047294-A1 | IMIDAZOLYL PYRIMIDINYLAMINE COMPOUNDS AS CDK2 INHIBITORS | INCYTE CORPORATION | 2021-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11427567-B2 | Imidazolyl pyrimidinylamine compounds as CDK2 inhibitors | CDK2, CDK4, CDK2AP2 | CCNE1 43/4885CDK2 1/4885CDK4 2/4885 |
| US-20210047294-A1 | IMIDAZOLYL PYRIMIDINYLAMINE COMPOUNDS AS CDK2 INHIBITORS | CDK2, CDK4, CDK2AP2 | CCNE1 43/4885CDK2 1/4885CDK4 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.