Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.63 |
| ▸ | PPARG | P37231 | 2/20 | 0.57 |
| ▸ | CTSS | P25774 | 4/20 | 0.56 |
| ▸ | KLK7 | P49862 | 2/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | CDC25A | P30304 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22980587 | 1.00 | PPARA (0.63) | PPARAPPARGCTSSKLK7KLK5 | |
| SCHEMBL31275389 | 0.91 | PPARA (0.60) | PPARAPPARGCTSSKLK7KLK5 | |
| SCHEMBL22990674 | 0.91 | PPARA (0.60) | PPARAPPARGCTSSKLK7KLK5 | |
| SCHEMBL28763859 | 0.91 | PPARA (0.60) | PPARAPPARGCTSSKLK7KLK5 | |
| SCHEMBL4126013 | 0.86 | PPARA (0.63) | PPARAPPARGCTSSKLK7KLK5 | |
| SCHEMBL271394 | 0.86 | PPARA (0.63) | PPARAPPARGCTSSKLK7KLK5 | |
| SCHEMBL2230694 | 0.86 | PPARA (0.63) | PPARAPPARGCTSSKLK7KLK5 | |
| SCHEMBL27422193 | 0.85 | PPARA (0.65) | PPARAPPARGCTSSKLK7KLK5 | |
| SCHEMBL4275630 | 0.85 | ATM (0.55) | PPARAPPARGCTSSKLK5ATM | |
| SCHEMBL5821214 | 0.85 | ATM (0.55) | PPARAPPARGCTSSKLK5ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010329-B9 | DEUTERATED COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LTD (GB) | 2023-10-04 | — | — | EP | disclosed |
| EP-4010329-B1 | DEUTERATED COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LTD (GB) | 2023-06-07 | — | — | EP | disclosed |
| CN-114846003-A | Deuterated compounds for the treatment of cancer | 阿提奥斯医药有限公司 | 2022-08-02 | — | — | CN | disclosed |
| EP-4010329-A1 | DEUTERATED COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | Artios Pharma Limited (GB) | 2022-06-15 | — | — | EP | disclosed |
| WO-2021028670-A1 | DEUTERATED COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |