Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 16/20 | 0.88 |
| ▸ | DAGLB | Q8NCG7 | 4/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2337122 | 0.94 | DAGLA (1.00) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2301073 | 0.85 | DAGLA (0.70) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2302253 | 0.85 | DAGLA (0.88) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2300570 | 0.82 | DAGLA (1.00) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6864007 | 0.80 | DAGLA (0.82) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2297486 | 0.80 | DAGLA (0.78) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2299131 | 0.80 | DAGLA (1.00) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2343368 | 0.79 | DAGLA (1.00) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2297110 | 0.78 | DAGLA (1.00) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2300879 | 0.76 | DAGLA (0.73) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536694-A1 | GLYCINE SULFONAMIDES FOR USE AS INHIBITORS OF DIACYLGLYCEROL LIPASE | Bristol-Myers Squibb Company (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011103055-A1 | GLYCINE SULFONAMIDES FOR USE AS INHIBITORS OF DIACYLGLYCEROL LIPASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-08-25 | — | — | WO | disclosed |