⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1637335 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL4071771 | 0.98 | — | — | |
| Hydrochloric Acid SCHEMBL82651 | 0.98 | — | — | |
| Oxalic Acid SCHEMBL12521042 | 0.91 | — | — | |
| SCHEMBL15111546 | 0.85 | — | — | |
| SCHEMBL15121099 | 0.85 | — | — | |
| SCHEMBL15111548 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL15111543 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL15111553 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL15111541 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1147254-A | Prodrugs of morpholine tachykinin receptor antagonists | MERCK & CO INC (US) | 1997-04-09 | — | — | CN | claimed |
| CN-104650143-B | The method for preparing fosaprepitant dimeglumine intermediate | 山东新时代药业有限公司 | 2018-10-02 | — | — | CN | disclosed |
| CN-102675369-B | One kind prepares [3 [(2R) [(1R) 1 [3,5 two (trifluoromethyl) phenyl] ethyoxyl] 3 (S) (4 fluorophenyl) morpholines 4 base] methyl] 5 oxos 4,5 dihydros [1,2,4] base of triazole 1] benzyl ester of phosphonic acids one new method | 北京华众思康医药技术有限公司 | 2017-07-11 | — | — | CN | disclosed |
| EP-2809661-B1 | NOVEL MORPHOLINYL DERIVATIVES USEFUL AS MOGAT-2 INHIBITORS | LILLY CO ELI (US) | 2016-04-06 | — | — | EP | disclosed |
| US-8993568-B2 | Morpholinyl derivatives useful as MOGAT-2 inhibitors | ELI LILLY AND COMPANY (US) | 2015-03-31 | — | — | US | disclosed |
| US-8940738-B2 | Pyrimidone compounds | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2015-01-27 | — | — | US | disclosed |
| US-8940738-B2 | Pyrimidone compounds | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2015-01-27 | — | — | US | disclosed |
| US-20150005305-A1 | NOVEL MORPHOLINYL DERIVATIVES USEFUL AS MOGAT-2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2015-01-01 | — | — | US | disclosed |
| CN-102675369-A | New method for preparing fosaprepitant intermediate | BEIJING HUAZHONGSIKANG PHARMACEUTICAL TECHNOLOGY CO LTD | 2012-09-19 | — | — | CN | disclosed |
| EP-2097409-B1 | 2-SUBSTITUTED-6-HETEROCYCLIC PYRIMIDONE DERIVATIVES AS TAU PROTEIN KINASE 1 INHBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-09-12 | — | — | EP | disclosed |
| EP-1558252-A2 | SUBSTITUTED FURO 2,3-B] PYRIDINE DERIVATIVES | Merck & Co., Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004012671-A2 | SUBSTITUTED FURO [2,3-B] PYRIDINE DERIVATIVES | MERCK & CO., INC. (US) | 2004-02-12 | — | — | WO | disclosed |
| CN-1131864-C | Chemical synthesis method of morpholine derivative | MERCK SHARP & DOHME LTD. (GB) | 2003-12-24 | — | — | CN | disclosed |
| CN-1075812-C | Prodrugs of morpholine tachykinin receptor antagonists | MERCK & CO INC (US) | 2001-12-05 | — | — | CN | disclosed |
| CN-1067683-C | Substituted morpholine derivatives and their use as therapeutic agents | MERK SHARP & DOHME LTD (GB) | 2001-06-27 | — | — | CN | disclosed |
| EP-0778831-A1 | MORPHOLINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 1997-06-18 | — | — | EP | disclosed |
| CN-1147254-A | Prodrugs of morpholine tachykinin receptor antagonists | MERCK & CO INC (US) | 1997-04-09 | — | — | CN | disclosed |
| CN-1139927-A | Substituted morpholine derivatives and their use as therapeutic agents | MERK SHARP & DOHME LTD (GB) | 1997-01-08 | — | — | CN | disclosed |
| EP-0748320-A1 | PRODRUGS OF MORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1996-12-18 | — | — | EP | disclosed |
| WO-1996007649-A1 | MORPHOLINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 1996-03-14 | — | — | WO | disclosed |