Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 16/20 | 0.73 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | LSS | P48449 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2298307 | 1.00 | FASN (0.73) | FASNRXFP1LSSMAPK10HSD17B10 | |
| SCHEMBL2354363 | 1.00 | FASN (0.73) | FASNRXFP1LSSMAPK10HSD17B10 | |
| SCHEMBL2300325 | 0.93 | FASN (0.67) | FASNRXFP1MAPK10HSD17B10 | |
| SCHEMBL14151928 | 0.89 | FASN (0.59) | FASN | |
| SCHEMBL2358609 | 0.89 | FASN (0.60) | FASN | |
| SCHEMBL2358613 | 0.89 | FASN (0.60) | FASN | |
| SCHEMBL2354954 | 0.88 | FASN (0.59) | FASN | |
| SCHEMBL12425206 | 0.88 | FASN (0.79) | FASN | |
| SCHEMBL14152430 | 0.87 | FASN (0.67) | FASN | |
| SCHEMBL12425401 | 0.87 | FASN (0.78) | FASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2538787-A1 | TRIAZOLONES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2013-01-02 | — | — | EP | disclosed |
| WO-2011103546-A1 | TRIAZOLONES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-08-25 | — | — | WO | disclosed |