Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 19/20 | 0.69 |
| ▸ | CDK6 | Q00534 | 19/20 | 0.69 |
| ▸ | CSF1R | P07333 | 13/20 | 0.69 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.69 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.62 |
| ▸ | CDK2 | P24941 | 3/20 | 0.62 |
| ▸ | CCNK | O75909 | 2/20 | 0.62 |
| ▸ | CDK9 | P50750 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29674879 | 0.91 | CDK4 (0.65) | CDK4CDK6CSF1RPIK3CDCCNA2 | |
| SCHEMBL30198682 | 0.88 | CDK4 (0.68) | CDK4CDK6CSF1RPIK3CDCCNA2 | |
| SCHEMBL21245535 | 0.88 | CDK4 (0.68) | CDK4CDK6CSF1RPIK3CDCCNA2 | |
| SCHEMBL29660551 | 0.86 | CDK4 (0.82) | CDK4CDK6CSF1RPIK3CDCCNA2 | |
| SCHEMBL28735927 | 0.86 | CDK4 (0.82) | CDK4CDK6CSF1RPIK3CDCCNA2 | |
| SCHEMBL21245608 | 0.85 | CDK4 (0.81) | CDK4CDK6CSF1RPIK3CDCCNA2 | |
| SCHEMBL30198564 | 0.85 | CDK4 (0.81) | CDK4CDK6CSF1RPIK3CDCCNA2 | |
| SCHEMBL21245616 | 0.82 | CDK4 (1.00) | CDK4CDK6CSF1RPIK3CDCCNA2 | |
| SCHEMBL21245865 | 0.82 | CDK4 (0.78) | CDK4CDK6CSF1RPIK3CDCCNA2 | |
| SCHEMBL21245617 | 0.81 | CDK4 (1.00) | CDK4CDK6CSF1RPIK3CDCCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4013743-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Nuvation Bio Inc. (US) | 2022-06-22 | — | — | EP | disclosed |
| WO-2021030623-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | NUVATION BIO INC. (US) | 2021-02-18 | — | — | WO | disclosed |