Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 19/20 | 0.73 |
| ▸ | TTK | P33981 | 1/20 | 0.56 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22985864 | 0.95 | LRRK2 (0.66) | LRRK2TTKMAP3K9MKNK2 | |
| SCHEMBL18018791 | 0.87 | LRRK2 (0.72) | LRRK2TTKMAP3K9MKNK2 | |
| SCHEMBL18018784 | 0.85 | LRRK2 (1.00) | LRRK2TTKMAP3K9MKNK2 | |
| SCHEMBL29429993 | 0.85 | LRRK2 (1.00) | LRRK2TTKMAP3K9MKNK2 | |
| SCHEMBL18018906 | 0.83 | LRRK2 (1.00) | LRRK2TTKMAP3K9MKNK2 | |
| SCHEMBL18018792 | 0.82 | LRRK2 (0.65) | LRRK2TTKMAP3K9MKNK2 | |
| SCHEMBL17980593 | 0.82 | LRRK2 (0.81) | LRRK2TTKMAP3K9MKNK2 | |
| SCHEMBL18018902 | 0.82 | LRRK2 (1.00) | LRRK2TTKMAP3K9MKNK2 | |
| SCHEMBL30718279 | 0.81 | LRRK2 (0.75) | LRRK2TTKMAP3K9MKNK2 | |
| SCHEMBL18018966 | 0.81 | LRRK2 (0.74) | LRRK2TTKMAP3K9MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778604-A1 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3778605-A2 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |