Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.54 |
| ▸ | INSR | P06213 | 11/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.54 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.54 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.54 |
| ▸ | IGF1R | P08069 | 6/20 | 0.52 |
| ▸ | ROS1 | P08922 | 3/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 2/20 | 0.48 |
| ▸ | GAK | O14976 | 2/20 | 0.48 |
| ▸ | ERN1 | O75460 | 2/20 | 0.48 |
| ▸ | STK10 | O94804 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | FYN | P06241 | 2/20 | 0.48 |
| ▸ | FES | P07332 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18018896 | 0.86 | ALK (0.53) | ALKINSRFGFR1FGFR2FGFR4 | |
| SCHEMBL18018897 | 0.82 | ALK (0.63) | ALKINSRFGFR1FGFR2FGFR4 | |
| SCHEMBL18018887 | 0.81 | ALK (0.76) | ALKINSRFGFR1FGFR2FGFR4 | |
| SCHEMBL18018889 | 0.81 | ALK (0.60) | ALKINSRFGFR1FGFR2FGFR4 | |
| SCHEMBL18018795 | 0.81 | ALK (0.69) | ALKINSRIGF1RABL1EGFR | |
| SCHEMBL18018898 | 0.80 | MAPK7 (0.48) | ALKINSRFGFR1FGFR2FGFR4 | |
| SCHEMBL18018886 | 0.79 | TTK (0.63) | ALKINSRFGFR1FGFR2FGFR4 | |
| SCHEMBL1545735 | 0.78 | ALK (0.61) | ALKINSRFGFR1FGFR2FGFR4 | |
| SCHEMBL12388986 | 0.78 | ALK (0.53) | ALKINSRFGFR1FGFR2FGFR4 | |
| SCHEMBL18018899 | 0.77 | ALK (0.53) | ALKINSRFGFR1FGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778604-A1 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3778605-A2 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |