Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 5/20 | 0.40 |
| ▸ | CA1 | P00915 | 5/20 | 0.40 |
| ▸ | CA2 | P00918 | 5/20 | 0.40 |
| ▸ | CA9 | Q16790 | 5/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10073751 | 0.89 | TDP1 (0.53) | MEN1GAAKMT2ATDP1IDO1 | |
| SCHEMBL25985418 | 0.85 | TDP1 (0.50) | MEN1GAAKMT2ATDP1IDO1 | |
| SCHEMBL22997280 | 0.85 | TDP1 (0.50) | MEN1GAAKMT2ATDP1IDO1 | |
| SCHEMBL38650561 | 0.85 | TDP1 (0.50) | MEN1GAAKMT2ATDP1IDO1 | |
| SCHEMBL14065889 | 0.85 | TDP1 (0.50) | MEN1GAAKMT2ATDP1IDO1 | |
| SCHEMBL30917974 | 0.83 | TDP1 (0.51) | MEN1GAAKMT2ATDP1IDO1 | |
| SCHEMBL16883899 | 0.81 | TDP1 (0.46) | MEN1GAAKMT2ATDP1IDO1 | |
| SCHEMBL13055393 | 0.80 | TDP1 (0.58) | MEN1GAAKMT2ATDP1IDO1 | |
| SCHEMBL13114987 | 0.80 | TDP1 (0.47) | MEN1GAAKMT2ATDP1IDO1 | |
| SCHEMBL13677262 | 0.79 | TDP1 (0.59) | MEN1GAAKMT2ATDP1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840688-B2 | Compositions and methods for inhibiting gene expression of Hif2alpha | Arrowhead Pharmaceuticals, Inc. (US) | 2023-12-12 | — | — | US | disclosed |
| US-10927373-B2 | Compositions and methods for inhibiting gene expression of Hif2alpha | Arrowhead Pharmaceuticals, Inc. (US) | 2021-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10927373-B2 | Compositions and methods for inhibiting gene expression of Hif2alpha | EPAS1, HIF1AN, EGLN2 | MEN1 3813/4885GAA 1572/4885KMT2A 513/4885 |
| US-11840688-B2 | Compositions and methods for inhibiting gene expression of Hif2alpha | EPAS1, HIF1AN, EGLN2 | MEN1 3813/4885GAA 1572/4885KMT2A 513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.