Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 7/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CLK1 | P49759 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | IL2 | P60568 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14705849 | 0.80 | NTRK1 (0.49) | CYP3A4MAP4K1CSF1RHTR1AKIT | |
| SCHEMBL3504849 | 0.78 | MAPK1 (0.44) | MAPK1CYP3A4CLK1DYRK1AMAP4K1 | |
| SCHEMBL22988849 | 0.77 | CSF1R (0.46) | MAPK1CYP3A4CLK1DYRK1AMAP4K1 | |
| SCHEMBL15102137 | 0.76 | CYP3A4 (0.63) | CYP3A4MAP4K1KLKB1CYP2C19CYP2D6 | |
| SCHEMBL29883593 | 0.76 | CYP3A4 (0.63) | CYP3A4MAP4K1KLKB1CYP2C19CYP2D6 | |
| SCHEMBL1267807 | 0.75 | CYP2C9 (0.61) | MAPK1CYP3A4CLK1DYRK1ACYP2C19 | |
| SCHEMBL22978460 | 0.73 | CSF1R (0.60) | CYP3A4CYP2C19CYP2D6CSF1R | |
| SCHEMBL22989186 | 0.73 | CYP3A4 (0.43) | CYP3A4MAP4K1CYP2C19CYP2D6BRD4 | |
| SCHEMBL31370208 | 0.72 | MAPK1 (0.43) | MAPK1CYP3A4CLK1DYRK1AMAP4K1 | |
| SCHEMBL3504846 | 0.72 | STAT6 (0.47) | MAPK1MAP4K1KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018233526-A9 | CSF1R INHIBITOR, AND MANUFACTURING METHOD THEREFOR AND APPLICATION THEREOF | 上海和誉生物医药科技有限公司 | 2021-02-18 | — | — | WO | disclosed |