Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15286803 | 0.87 | POLB (0.55) | CYP1A2KMT2ALCKPARP1KDM4E | |
| SCHEMBL30163484 | 0.87 | POLB (0.55) | CYP1A2KMT2ALCKPARP1KDM4E | |
| SCHEMBL9015187 | 0.83 | CYP1A2 (0.53) | CYP1A2KMT2ALMNAMEN1 | |
| SCHEMBL6880429 | 0.83 | TDP1 (0.59) | CYP1A2KMT2AKDM4EMEN1 | |
| SCHEMBL2224282 | 0.81 | TDP1 (0.58) | CYP1A2KMT2AKDM4EMEN1 | |
| SCHEMBL27503111 | 0.80 | KMT2A (0.48) | CYP1A2KMT2ALCKKDM4ECHEK2 | |
| Lithium Ion SCHEMBL2224280 | 0.80 | CYP1A2 (0.50) | CYP1A2KMT2AMEN1 | |
| SCHEMBL19691192 | 0.79 | LCK (0.53) | KMT2ALCKPARP1KDM4EGLA | |
| SCHEMBL9945611 | 0.79 | KDM4E (0.51) | CYP1A2KMT2ALCKKDM4EGLA | |
| SCHEMBL31435439 | 0.79 | KDM4E (0.51) | CYP1A2KMT2ALCKKDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-A1 | NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | Polichem SA (LU) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080264-A1 | NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM S.A. (LU) | 2011-07-07 | — | — | WO | disclosed |