Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.76 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14256080 | 0.94 | NR1H2 (0.68) | NR1H2NAMPTUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL72498 | 0.93 | NR1H2 (0.75) | NR1H2NAMPTUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL16633724 | 0.90 | NR1H2 (0.68) | NR1H2NAMPTUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL16633725 | 0.90 | NR1H2 (0.68) | NR1H2NAMPTUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL2897311 | 0.90 | NR1H2 (0.68) | NR1H2NAMPTUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL4559486 | 0.90 | NR1H2 (0.68) | NR1H2NAMPTUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL4245398 | 0.90 | NR1H2 (0.68) | NR1H2NAMPTUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL12527166 | 0.89 | NR1H2 (0.66) | NR1H2NAMPTUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL27159056 | 0.88 | NR1H2 (0.64) | NR1H2NAMPTUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL23406722 | 0.86 | NR1H2 (1.00) | NR1H2NAMPTUSP2SMN1; SMN2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011103127-A1 | TREATMENT OF METABOLIC SYNDROME WITH PIPERIDINE AMIDES | AMPLA PHARMACEUTICALS INC. (US) | 2011-08-25 | — | — | WO | disclosed |
| WO-2011103127-A1 | TREATMENT OF METABOLIC SYNDROME WITH PIPERIDINE AMIDES | AMPLA PHARMACEUTICALS INC. (US) | 2011-08-25 | — | — | WO | disclosed |
| US-7338965-B2 | 3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines | PHARMACIA & UPJOHN COMPANY (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338965-B2 | 3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines | PHARMACIA & UPJOHN COMPANY (US) | 2008-03-04 | — | — | US | disclosed |