Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | F12 | P00748 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24253310 | 0.81 | CYP2C19 (0.38) | CYP2C19CHRM3GAACYP1A2POLB | |
| SCHEMBL23921831 | 0.80 | PDE10A (0.35) | PDE10AGAACYP1A2POLBDRD2 | |
| SCHEMBL14861241 | 0.78 | POLB (0.39) | PDE10AGAAPOLBDRD2DRD4 | |
| SCHEMBL12871625 | 0.76 | GAA (0.53) | PDE10AGAACYP1A2POLBALDH1A1 | |
| SCHEMBL15345110 | 0.76 | CYP2C19 (0.44) | CYP2C19CHRM3GAACYP1A2POLB | |
| SCHEMBL23921809 | 0.70 | HTR2C (0.38) | CHRM3GAACYP1A2POLBF12 | |
| SCHEMBL22993455 | 0.68 | CYP2C19 (0.32) | CYP2C19GAAPOLBALDH1A1LMNA | |
| SCHEMBL17234811 | 0.68 | PDE10A (0.38) | CYP2C19PDE10ACHRM3CYP1A2 | |
| SCHEMBL26145772 | 0.64 | C5AR1 (0.42) | GAADRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL17234815 | 0.64 | GAA (0.34) | CYP2C19PDE10ACHRM3GAAADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021028649-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |
| WO-2021028645-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |