Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17384788 | 0.91 | EGFR (0.62) | EGFRKCNH2IGF1RERBB2ERBB3 | |
| SCHEMBL22510212 | 0.90 | EGFR (0.47) | EGFRKCNH2IGF1R | |
| SCHEMBL17683180 | 0.88 | EGFR (0.61) | EGFRKCNH2IGF1RERBB2ERBB3 | |
| SCHEMBL19325652 | 0.87 | EGFR (0.55) | EGFRKCNH2IGF1RERBB2ERBB3 | |
| SCHEMBL17384765 | 0.87 | EGFR (0.62) | EGFRKCNH2IGF1RERBB2ERBB3 | |
| SCHEMBL22994862 | 0.87 | EGFR (0.54) | EGFRKCNH2IGF1R | |
| SCHEMBL17373135 | 0.85 | EGFR (0.59) | EGFRKCNH2IGF1RERBB2ERBB3 | |
| SCHEMBL22994975 | 0.84 | EGFR (0.57) | EGFRKCNH2IGF1RERBB2ERBB3 | |
| SCHEMBL22510215 | 0.84 | EGFR (0.59) | EGFRKCNH2IGF1RERBB2ERBB3 | |
| SCHEMBL22510199 | 0.83 | EGFR (0.56) | EGFRKCNH2IGF1RERBB2ERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778584-A1 | PRODUCTION PROCESS OF 2-CHLORO-4-HETEROARYL-PYRIMIDINE DERIVATIVES | ARIAD Pharmaceuticals, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |