Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 20/20 | 0.69 |
| ▸ | DAGLB | Q8NCG7 | 4/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27888089 | 0.88 | DAGLA (0.62) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2298993 | 0.86 | DAGLA (0.76) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2301024 | 0.85 | DAGLA (0.81) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL27888096 | 0.85 | DAGLA (0.63) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2296613 | 0.83 | DAGLA (0.82) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2303316 | 0.82 | DAGLA (0.81) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2296498 | 0.82 | DAGLA (1.00) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2299052 | 0.82 | DAGLA (0.79) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2299011 | 0.81 | DAGLA (0.70) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2296985 | 0.79 | DAGLA (1.00) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536694-A1 | GLYCINE SULFONAMIDES FOR USE AS INHIBITORS OF DIACYLGLYCEROL LIPASE | Bristol-Myers Squibb Company (US) | 2012-12-26 | — | — | EP | claimed |
| WO-2011103055-A1 | GLYCINE SULFONAMIDES FOR USE AS INHIBITORS OF DIACYLGLYCEROL LIPASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-08-25 | — | — | WO | claimed |