Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.72 |
| ▸ | CCNE1 | P24864 | 15/20 | 0.72 |
| ▸ | CCND1 | P24385 | 12/20 | 0.43 |
| ▸ | CDK1 | P06493 | 11/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 11/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 11/20 | 0.43 |
| ▸ | CDK4 | P11802 | 11/20 | 0.43 |
| ▸ | CCND3 | P30281 | 10/20 | 0.43 |
| ▸ | ULK1 | O75385 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 4/20 | 0.42 |
| ▸ | CCNH | P51946 | 4/20 | 0.42 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.42 |
| ▸ | CDK9 | P50750 | 4/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22997746 | 0.89 | CCNE1 (0.58) | CDK2CCNE1CCND1CDK1CCNB1 | |
| SCHEMBL23001263 | 0.89 | CDK2 (0.58) | CDK2CCNE1CCND1CDK1CCNB1 | |
| SCHEMBL22997728 | 0.87 | CCNE1 (0.56) | CDK2CCNE1CCND1CDK1CCNB1 | |
| SCHEMBL22976992 | 0.84 | CCNE1 (1.00) | CDK2CCNE1CCND1CDK1CCNB1 | |
| SCHEMBL22997726 | 0.84 | CDK2 (0.74) | CDK2CCNE1CCND1CDK1CCNB1 | |
| SCHEMBL26268744 | 0.82 | CCNE1 (0.49) | CDK2CCNE1CCND1CDK1CCNB1 | |
| SCHEMBL22997720 | 0.82 | CCNE1 (0.55) | CDK2CCNE1CCND1CDK1CCNB1 | |
| SCHEMBL22997662 | 0.81 | CCNE1 (0.48) | CDK2CCNE1CCND1CDK1CCNB1 | |
| SCHEMBL22997623 | 0.80 | CDK2 (0.53) | CDK2CCNE1CCND1CDK1CCNB1 | |
| SCHEMBL26267828 | 0.80 | CDK2 (0.48) | CDK2CCNE1CCND1CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021030537-A1 | IMIDAZOLYL PYRIMIDINYLAMINE COMPOUNDS AS CDK2 INHIBITORS | INCYTE CORPORATION (US) | 2021-02-18 | — | — | WO | disclosed |