Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 18/20 | 0.58 |
| ▸ | CDK2 | P24941 | 18/20 | 0.58 |
| ▸ | CCND1 | P24385 | 14/20 | 0.58 |
| ▸ | CDK6 | Q00534 | 14/20 | 0.58 |
| ▸ | CDK4 | P11802 | 8/20 | 0.58 |
| ▸ | CCND3 | P30281 | 8/20 | 0.58 |
| ▸ | CDK1 | P06493 | 8/20 | 0.58 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.58 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.58 |
| ▸ | CDK7 | P50613 | 4/20 | 0.58 |
| ▸ | CDK9 | P50750 | 4/20 | 0.58 |
| ▸ | CCNH | P51946 | 4/20 | 0.58 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22977251 | 1.00 | CCNE1 (0.58) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22977289 | 1.00 | CCNE1 (0.58) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22977120 | 0.93 | CCNE1 (0.57) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22977082 | 0.93 | CCNE1 (0.57) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22977344 | 0.92 | CCNE1 (0.58) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22977116 | 0.89 | CCNE1 (0.57) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22976940 | 0.88 | CCNE1 (0.73) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22977186 | 0.87 | CCNE1 (0.46) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22977087 | 0.86 | CCNE1 (0.46) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22901212 | 0.86 | CCNE1 (0.78) | CCNE1CDK2CCND1CDK6CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021030537-A1 | IMIDAZOLYL PYRIMIDINYLAMINE COMPOUNDS AS CDK2 INHIBITORS | INCYTE CORPORATION (US) | 2021-02-18 | — | — | WO | disclosed |