Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 13/20 | 0.48 |
| ▸ | CDK2 | P24941 | 13/20 | 0.48 |
| ▸ | CDK4 | P11802 | 10/20 | 0.48 |
| ▸ | CCND1 | P24385 | 10/20 | 0.48 |
| ▸ | CCND3 | P30281 | 10/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 10/20 | 0.48 |
| ▸ | CDK1 | P06493 | 10/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 10/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.48 |
| ▸ | CDK7 | P50613 | 6/20 | 0.48 |
| ▸ | CDK9 | P50750 | 6/20 | 0.48 |
| ▸ | CCNH | P51946 | 6/20 | 0.48 |
| ▸ | MNAT1 | P51948 | 6/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22977445 | 1.00 | CCNE1 (0.48) | CCNE1CDK2CDK4CCND1CCND3 | |
| SCHEMBL22977255 | 0.92 | CCNE1 (0.41) | CCNE1CDK2CDK4CCND1CCND3 | |
| SCHEMBL22977292 | 0.91 | CCNE1 (0.39) | CCNE1CDK2CDK4CCND1CCND3 | |
| SCHEMBL29820833 | 0.91 | CCNE1 (0.39) | CCNE1CDK2CDK4CCND1CCND3 | |
| SCHEMBL22977076 | 0.89 | CCNE1 (0.39) | CCNE1CDK2CDK4CCND1CCND3 | |
| SCHEMBL22977382 | 0.86 | CCNE1 (0.47) | CCNE1CDK2CDK4CCND1CCND3 | |
| SCHEMBL22997681 | 0.86 | CCNE1 (0.47) | CCNE1CDK2CDK4CCND1CCND3 | |
| SCHEMBL22977027 | 0.84 | CCNE1 (0.47) | CCNE1CDK2CDK4CCND1CCND3 | |
| SCHEMBL22977436 | 0.83 | CCNE1 (0.36) | CCNE1CDK2CDK4CCND1CCND3 | |
| SCHEMBL22997743 | 0.81 | CDK4 (0.40) | CCNE1CDK2CDK4CCND1CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021030537-A1 | IMIDAZOLYL PYRIMIDINYLAMINE COMPOUNDS AS CDK2 INHIBITORS | INCYTE CORPORATION (US) | 2021-02-18 | — | — | WO | disclosed |