Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 13/20 | 0.46 |
| ▸ | AKT2 | P31751 | 5/20 | 0.46 |
| ▸ | AKT3 | Q9Y243 | 5/20 | 0.46 |
| ▸ | PRKCB | P05771 | 4/20 | 0.46 |
| ▸ | PRKCA | P17252 | 4/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 2/20 | 0.46 |
| ▸ | PRKACB | P22694 | 2/20 | 0.46 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.46 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
| ▸ | SGK1 | O00141 | 3/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.45 |
| ▸ | PRKCG | P05129 | 3/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.45 |
| ▸ | PRKCH | P24723 | 3/20 | 0.45 |
| ▸ | PRKCI | P41743 | 3/20 | 0.45 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2300080 | 1.00 | AKT1 (0.46) | AKT1AKT2AKT3PRKCBPRKCA | |
| SCHEMBL2302214 | 0.86 | AKT1 (0.55) | AKT1AKT2AKT3PRKCBPRKCA | |
| SCHEMBL12385393 | 0.86 | AKT1 (0.55) | AKT1AKT2AKT3PRKCBPRKCA | |
| SCHEMBL2299884 | 0.86 | AKT1 (0.55) | AKT1AKT2AKT3PRKCBPRKCA | |
| SCHEMBL3125109 | 0.85 | AKT1 (0.47) | AKT1AKT2AKT3PRKCBPRKCA | |
| SCHEMBL3125113 | 0.85 | AKT1 (0.47) | AKT1AKT2AKT3PRKCBPRKCA | |
| SCHEMBL12385390 | 0.84 | AKT1 (0.44) | AKT1AKT2AKT3PRKCBPRKCA | |
| SCHEMBL12424921 | 0.84 | AKT1 (0.44) | AKT1AKT2AKT3PRKCBPRKCA | |
| SCHEMBL2304468 | 0.83 | AKT1 (0.44) | AKT1AKT2AKT3PRKCBPRKCA | |
| SCHEMBL2302178 | 0.80 | AKT1 (0.56) | AKT1AKT2AKT3PRKCBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110196009-A1 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION | 2011-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110196009-A1 | INHIBITORS OF Akt ACTIVITY | AKT2, AKT1, AKT3 | AKT1 2/4885AKT2 1/4885AKT3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.