Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.56 |
| ▸ | CDK7 | P50613 | 6/20 | 0.46 |
| ▸ | CCNH | P51946 | 6/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 6/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | CCNK | O75909 | 4/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 4/20 | 0.44 |
| ▸ | BRD4 | O60885 | 4/20 | 0.43 |
| ▸ | ATAD2 | Q6PL18 | 4/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23003223 | 1.00 | MAPK8 (0.56) | MAPK8MAPK9MAPK10CDK7CCNH | |
| SCHEMBL23003107 | 0.92 | MAPK8 (0.56) | MAPK8MAPK9MAPK10CDK7CCNH | |
| SCHEMBL23003112 | 0.92 | MAPK8 (0.56) | MAPK8MAPK9MAPK10CDK7CCNH | |
| SCHEMBL17910207 | 0.80 | MAPK8 (0.66) | MAPK8MAPK9MAPK10CDK7CCNH | |
| SCHEMBL3052427 | 0.80 | MAPK8 (0.60) | MAPK8MAPK9MAPK10CDK7CCNH | |
| SCHEMBL16802771 | 0.80 | MAPK8 (0.66) | MAPK8MAPK9MAPK10CDK7CCNH | |
| SCHEMBL16802784 | 0.80 | MAPK8 (0.63) | MAPK8MAPK9MAPK10CDK7CCNH | |
| SCHEMBL18148274 | 0.80 | MAPK8 (0.63) | MAPK8MAPK9MAPK10CDK7CCNH | |
| SCHEMBL17910138 | 0.80 | MAPK8 (0.56) | MAPK8MAPK9MAPK10CDK7CCNH | |
| SCHEMBL17910154 | 0.78 | MAPK8 (0.60) | MAPK8MAPK9MAPK10CDK7CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11447493-B2 | Inhibitors of cyclin-dependent kinases | KINNATE BIOPHARMA INC. | 2022-09-20 | — | — | US | disclosed |
| EP-3787629-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | Kinnate Biopharma Inc. (US) | 2021-03-10 | — | — | EP | disclosed |
| US-20210053969-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | KINNATE BIOPHARMA INC. | 2021-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210053969-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | CDK2, CCNK, CDK1 | MAPK8 336/4885MAPK9 253/4885MAPK10 401/4885 |
| US-11447493-B2 | Inhibitors of cyclin-dependent kinases | CDK2, CCNK, CDK1 | MAPK8 336/4885MAPK9 253/4885MAPK10 401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.