Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 18/20 | 0.43 |
| ▸ | JAK2 | O60674 | 17/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24264915 | 0.87 | JAK1 (0.44) | JAK1JAK2MEN1ALDH1A1MAPT | |
| SCHEMBL30713526 | 0.81 | JAK1 (0.58) | JAK1JAK2MEN1ALDH1A1MAPT | |
| SCHEMBL9921830 | 0.80 | MEN1 (0.44) | JAK1JAK2MEN1ALDH1A1MAPT | |
| SCHEMBL34474310 | 0.79 | NR1H2 (0.41) | — | |
| SCHEMBL34473415 | 0.79 | USP2 (0.39) | CTSK | |
| SCHEMBL26148291 | 0.79 | MEN1 (0.43) | JAK1JAK2MEN1ALDH1A1MAPT | |
| SCHEMBL25270241 | 0.78 | MEN1 (0.45) | JAK1JAK2MEN1ALDH1A1MAPT | |
| SCHEMBL25693158 | 0.78 | JAK1 (0.41) | JAK1JAK2 | |
| SCHEMBL24584618 | 0.77 | JAK1 (0.43) | JAK1JAK2MEN1ALDH1A1MAPT | |
| SCHEMBL346150 | 0.77 | JAK1 (0.43) | JAK1JAK2MEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4011865-A1 | BRIDGED HETEROCYCLYL-SUBSTITUTED PYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | The National Institutes of Pharmaceutical R&D Co., Ltd (CN) | 2022-06-15 | — | — | EP | disclosed |
| WO-2021027647-A1 | BRIDGED HETEROCYCLYL-SUBSTITUTED PYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | 中国医药研究开发中心有限公司 | 2021-02-18 | — | — | WO | disclosed |