⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1372807 | 0.93 | — | — | |
| SCHEMBL11970594 | 0.93 | — | — | |
| SCHEMBL19277256 | 0.91 | — | — | |
| SCHEMBL20713833 | 0.90 | — | — | |
| SCHEMBL34476132 | 0.86 | — | — | |
| SCHEMBL2331632 | 0.81 | — | — | |
| SCHEMBL16323061 | 0.76 | HCAR2 (0.30) | — | |
| SCHEMBL16323060 | 0.76 | HCAR2 (0.30) | — | |
| SCHEMBL20971980 | 0.76 | — | — | |
| SCHEMBL31116468 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260078117-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS INC (US) | 2026-03-19 | — | — | US | disclosed |
| CN-120018863-A | Methods and compositions for modulating KRAS (G12D) | 珃诺生物医药科技(杭州)有限公司 | 2025-05-16 | — | — | CN | disclosed |
| US-20240279219-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2024-08-22 | — | — | US | disclosed |
| US-20240228478-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2024-07-11 | — | — | US | disclosed |
| CN-117794930-A | KRAS inhibitors | 苏州亚盛药业有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-116568677-A | piperidin-1-yl-N-pyridin-3-yl-2-oxoacetamide derivatives useful for the treatment of MTAP deficiency and/or MTA accumulating cancers | 探戈医药股份有限公司 | 2023-08-08 | — | — | CN | disclosed |
| EP-4188920-A1 | PIPERIDIN-1-YL-N-PYRYDINE-3-YL-2-OXOACETAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF MTAP-DEFICIENT AND/OR MTA-ACCUMULATING CANCERS | Tango Therapeutics, Inc. (US) | 2023-06-07 | — | — | EP | disclosed |
| WO-2023030495-A1 | KRAS INHIBITORS | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2023-03-09 | — | — | WO | disclosed |
| CN-115611924-A | PD-1/PD-L1 inhibitor and preparation method and application thereof | 上海华汇拓医药科技有限公司 | 2023-01-17 | — | — | CN | disclosed |
| WO-2022199586-A1 | PYRIMIDOPYRIDINE INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF | 苏州泽璟生物制药股份有限公司 | 2022-09-29 | — | — | WO | disclosed |
| CN-105745212-B | Spiro derivatives of substituted 4, 5-dihydropyrazolo [3,4-c ] pyridin-2-ones and uses thereof | 四川海思科制药有限公司 | 2017-09-12 | — | — | CN | disclosed |
| CN-105745212-A | Spiro derivatives of substituted 4, 5-dihydropyrazolo [3,4-c ] pyridin-2-ones and uses thereof | 四川海思科制药有限公司 | 2016-07-06 | — | — | CN | disclosed |
| CN-104395312-B | The Spirocyclic derivatives of 4,5-dihydro-pyrazolo [3,4-c] pyridin-2-ones, its preparation method and application | SICHUAN HAISCO PHARMACEUTICAL CO.,LTD. (CN) | 2016-04-27 | — | — | CN | disclosed |
| WO-2015081901-A1 | SUBSTITUTED 4, 5-DIHYDROPYRAZOLO [3, 4-C] PYRIDINE-2-ONE SPIROCYCLIC DERIVATIVE, AND USE THEREOF | 四川海思科制药有限公司 | 2015-06-11 | — | — | WO | disclosed |
| CN-104395312-A | Substituted azabicycles and use thereof | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2015-03-04 | — | — | CN | disclosed |
| WO-2014202027-A1 | SPIROCYCLIC DERIVATIVE OF 4,5-DIHYDROPYRAZOLO[3,4-C]PYRIDINE-2-ONE, PREPARATION METHOD AND USE THEREOF | 四川海思科制药有限公司 (CN) | 2014-12-24 | — | — | WO | disclosed |
| WO-2014202027-A1 | SPIROCYCLIC DERIVATIVE OF 4,5-DIHYDROPYRAZOLO[3,4-C]PYRIDINE-2-ONE, PREPARATION METHOD AND USE THEREOF | 四川海思科制药有限公司 (CN) | 2014-12-24 | — | — | WO | disclosed |
| US-7998959-B2 | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same | INCYTE CORPORATION (US) | 2011-08-16 | — | — | US | disclosed |
| US-20070197506-A1 | Modulators of 11-beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same | INCYTE CORPORATION | 2007-08-23 | — | — | US | disclosed |
| WO-2007084314-A2 | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME | INCYTE CORPORATION (US) | 2007-07-26 | — | — | WO | disclosed |