Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17623918 | 0.81 | MAPT (0.67) | MAPTMAPK1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL23010794 | 0.79 | MEN1 (0.53) | MAPTMAPK1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL20274800 | 0.79 | SLC6A2 (0.48) | MAPTMAPK1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL4528068 | 0.79 | NPC1 (0.67) | MAPTMAPK1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL446237 | 0.79 | MAPT (0.63) | MAPTMAPK1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL8666534 | 0.76 | KMT2A (1.00) | MAPTMAPK1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL19317589 | 0.76 | MAPT (0.59) | MAPTMAPK1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL16579676 | 0.75 | MAPT (0.58) | MAPTMAPK1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL11256504 | 0.75 | MAPT (0.58) | MAPTMAPK1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL10966164 | 0.73 | CYP1A2 (0.85) | MAPTMAPK1CYP1A2CYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3194385-B3 | N-(HETERO)ARYL-SUBSTITUTED HETEROYCLIC DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES OR CONDITIONS RELATED TO THE CENTRAL NERVOUS SYSTEM | CHRONOS THERAPEUTICS LTD (GB) | 2021-02-17 | — | — | EP | disclosed |