Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.61 |
| ▸ | JAK3 | P52333 | 20/20 | 0.61 |
| ▸ | JAK1 | P23458 | 19/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2233140 | 1.00 | JAK2 (0.61) | JAK2JAK3JAK1 | |
| SCHEMBL2345611 | 0.90 | JAK2 (0.74) | JAK2JAK3JAK1 | |
| SCHEMBL2232039 | 0.90 | JAK2 (0.74) | JAK2JAK3JAK1 | |
| SCHEMBL12346505 | 0.90 | JAK2 (0.51) | JAK2JAK3JAK1 | |
| SCHEMBL2346942 | 0.88 | JAK2 (0.48) | JAK2JAK3JAK1 | |
| SCHEMBL2234558 | 0.88 | JAK2 (0.60) | JAK2JAK3JAK1 | |
| SCHEMBL12346437 | 0.88 | JAK2 (0.60) | JAK2JAK3JAK1 | |
| SCHEMBL2230954 | 0.88 | JAK2 (0.56) | JAK2JAK3JAK1 | |
| SCHEMBL2350469 | 0.86 | JAK2 (0.58) | JAK2JAK3JAK1 | |
| SCHEMBL2350472 | 0.86 | JAK2 (0.58) | JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536728-A1 | PYRAZOLE DERIVATIVES AS JAK INHIBITORS | Almirall S.A. (ES) | 2012-12-26 | — | — | EP | claimed |
| WO-2011101161-A1 | PYRAZOLE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-08-25 | — | — | WO | claimed |
| EP-2360158-A1 | Pyrazole derivatives as jak inhibitors | Almirall, S.A. (ES) | 2011-08-24 | — | — | EP | claimed |
| EP-2360158-A1 | Pyrazole derivatives as jak inhibitors | Almirall, S.A. (ES) | 2011-08-24 | — | — | EP | disclosed |