Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 12/20 | 0.70 |
| ▸ | FPR3 | P25089 | 2/20 | 0.51 |
| ▸ | FPR2 | P25090 | 2/20 | 0.51 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18124204 | 1.00 | USP30 (0.70) | USP30FPR3FPR2RIPK1HDAC4 | |
| SCHEMBL29779090 | 1.00 | USP30 (0.70) | USP30FPR3FPR2RIPK1HDAC4 | |
| SCHEMBL28513485 | 0.88 | USP30 (0.67) | USP30RIPK1HDAC4HDAC6PARP1 | |
| SCHEMBL18124183 | 0.88 | USP30 (0.67) | USP30RIPK1HDAC4HDAC6PARP1 | |
| SCHEMBL29778997 | 0.88 | USP30 (0.67) | USP30RIPK1HDAC4HDAC6PARP1 | |
| SCHEMBL18115999 | 0.83 | USP30 (0.49) | USP30 | |
| SCHEMBL19990877 | 0.83 | USP30 (0.49) | USP30 | |
| SCHEMBL3720765 | 0.82 | USP30 (0.65) | USP30FPR3FPR2HDAC4HDAC6 | |
| SCHEMBL18124184 | 0.82 | USP30 (1.00) | USP30FPR3FPR2 | |
| SCHEMBL26187387 | 0.82 | USP30 (0.59) | USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3943490-A1 | 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS | Mission Therapeutics Limited (GB) | 2022-01-26 | — | — | EP | disclosed |
| EP-3277677-B9 | 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS | MISSION THERAPEUTICS LTD (GB) | 2021-07-14 | — | — | EP | disclosed |
| EP-3842427-A1 | 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS | Mission Therapeutics Limited (GB) | 2021-06-30 | — | — | EP | disclosed |
| CN-112707893-A | 1-cyanopyrrolidine compounds as USP30 inhibitors | 特殊治疗有限公司 | 2021-04-27 | — | — | CN | disclosed |
| EP-3277677-B1 | 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS | MISSION THERAPEUTICS LTD (GB) | 2021-02-24 | — | — | EP | disclosed |
| CN-107484415-B | 1-cyanopyrrolidine compounds as USP30 inhibitors | 特殊治疗有限公司 | 2021-01-29 | — | — | CN | disclosed |