SCHEMBL23020110

SCHEMBL23020110

N#Cc1cc(-c2ccc(-c3cccc4cccnc34)cc2)cc(-c2ccc(-c3ccc(-c4nc(-c5ccccc5)c5ccccc5n4)cc3)c3ccccc23)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 8/20 0.42
CYP3A4 P08684 7/20 0.42
MEN1 O00255 6/20 0.42
KMT2A Q03164 6/20 0.42
ALDH1A1 P00352 5/20 0.42
CLK4 Q9HAZ1 4/20 0.42
HSD17B10 Q99714 4/20 0.42
LMNA P02545 4/20 0.42
TSHR P16473 4/20 0.42
CYP2D6 P10635 4/20 0.42
CYP2C19 P33261 3/20 0.42
CYP2C9 P11712 3/20 0.42
ADORA2A P29274 1/20 0.42
ATM Q13315 1/20 0.41
MAPK1 P28482 3/20 0.40
ABCG2 Q9UNQ0 7/20 0.39
TP53 P04637 2/20 0.39
PDE4A P27815 1/20 0.39
PDE4C Q08493 1/20 0.39
PDE4D Q08499 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23020178 0.91 ABCG2 (0.43) CYP1A2CYP3A4MEN1KMT2AALDH1A1
SCHEMBL23020075 0.89 ABCG2 (0.41) CYP1A2CYP3A4MEN1KMT2AALDH1A1
SCHEMBL23020162 0.85 MEN1 (0.44) CYP1A2CYP3A4MEN1KMT2AALDH1A1
SCHEMBL22652772 0.85 ADORA2A (0.55) CYP1A2CYP3A4MEN1KMT2AALDH1A1
SCHEMBL23020374 0.84 ABCG2 (0.39) CYP1A2CYP3A4MEN1KMT2AALDH1A1
SCHEMBL24407003 0.84 CYP1A2 (0.43) CYP1A2CYP3A4MEN1KMT2AALDH1A1
SCHEMBL23606550 0.84 MEN1 (0.58) MEN1KMT2AADORA2AATM
SCHEMBL16436461 0.84 MEN1 (0.54) CYP3A4MEN1KMT2ALMNATSHR
SCHEMBL23020058 0.82 PDE4A (0.42) CLK4ABCG2PDE4APDE4CPDE4D
SCHEMBL23020111 0.82 MEN1 (0.48) CYP1A2CYP3A4MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3392242-B1 NOVEL HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE USING SAME LG CHEMICAL LTD (KR) 2021-02-24 EP disclosed