Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 3/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.30 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2302144 | 1.00 | PDE9A (0.39) | PDE9AFLT3CDK4CDK6 | |
| SCHEMBL2302147 | 1.00 | PDE9A (0.39) | PDE9AFLT3CDK4CDK6 | |
| SCHEMBL2077826 | 0.94 | PDE9A (0.39) | PDE9AFLT3 | |
| SCHEMBL2305299 | 0.91 | FLT3 (0.38) | FLT3 | |
| SCHEMBL2300436 | 0.91 | FLT3 (0.38) | FLT3 | |
| SCHEMBL2300439 | 0.91 | FLT3 (0.38) | FLT3 | |
| SCHEMBL2075684 | 0.87 | PDE9A (0.39) | PDE9A | |
| SCHEMBL2078452 | 0.86 | PDE9A (0.35) | PDE9A | |
| SCHEMBL2077472 | 0.86 | PDE9A (0.35) | PDE9A | |
| SCHEMBL13007364 | 0.86 | PDE9A (0.35) | PDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024360-B1 | SUBSTITUTED PYRAZOLOPYRIMIDINES | CEPHALON INC (US) | 2013-04-03 | — | — | EP | claimed |
| US-7851468-B2 | Substituted pyrazolo[3,4-d]pyrimidines | CEPHALON, INC. (US) | 2010-12-14 | — | — | US | claimed |
| EP-2024360-B1 | SUBSTITUTED PYRAZOLOPYRIMIDINES | CEPHALON INC (US) | 2013-04-03 | — | — | EP | disclosed |
| EP-2351751-A1 | Substituted pyrazolopyrimidines | CEPHALON, INC. (US) | 2011-08-03 | — | — | EP | disclosed |
| EP-2024360-A2 | SUBSTITUTED PYRAZOLOPYRIMIDINES | Cephalon, Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2008063232-A2 | SUBSTITUTED PYRAZOLOPYRIMIDINES | CEPHALON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |