Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19991832 | 0.93 | FLT3 (0.42) | FLT3TYRO3MERTKGAS6MAPT | |
| SCHEMBL19940963 | 0.93 | FLT3 (0.42) | FLT3TYRO3MERTKGAS6MAPT | |
| SCHEMBL18109627 | 0.92 | TLR8 (0.46) | FLT3TYRO3MERTKGAS6MAPT | |
| SCHEMBL19941010 | 0.92 | FLT3 (0.41) | FLT3TYRO3MERTKGAS6MAPT | |
| SCHEMBL18109624 | 0.92 | TLR8 (0.46) | FLT3TYRO3MERTKGAS6MAPT | |
| SCHEMBL19940928 | 0.91 | FLT3 (0.41) | FLT3TYRO3MERTKGAS6MAPT | |
| SCHEMBL18125251 | 0.91 | TLR8 (0.46) | FLT3TYRO3MERTKGAS6MAPT | |
| SCHEMBL18109427 | 0.91 | TLR8 (0.46) | FLT3TYRO3MERTKGAS6MAPT | |
| SCHEMBL19991843 | 0.91 | FLT3 (0.41) | FLT3TYRO3MERTKGAS6MAPT | |
| SCHEMBL23025780 | 0.91 | FLT3 (0.41) | FLT3TYRO3MERTKGAS6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4019517-A1 | 2-AMINOPYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | Shanghai Zhimeng Biopharma, Inc. (CN) | 2022-06-29 | — | — | EP | disclosed |
| WO-2021031960-A1 | 2-AMINOPYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | 上海挚盟医药科技有限公司 | 2021-02-25 | — | — | WO | disclosed |