SCHEMBL23027348

SCHEMBL23027348

O=C(Nc1cc[nH]c(=O)c1)c1cc(Cl)c(C(F)(F)F)cc1Oc1ccc(F)c2c1CCC2

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN8A Q9UQD0 20/20 0.58
SCN10A Q9Y5Y9 20/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23027445 0.98 SCN8A (0.58) SCN8ASCN10A
SCHEMBL23027519 0.91 SCN8A (0.55) SCN8ASCN10A
SCHEMBL23027434 0.90 SCN8A (0.56) SCN8ASCN10A
SCHEMBL23027451 0.88 SCN8A (0.55) SCN8ASCN10A
SCHEMBL23027439 0.88 SCN8A (0.56) SCN8ASCN10A
SCHEMBL23027347 0.88 SCN10A (0.56) SCN8ASCN10A
SCHEMBL23027350 0.88 SCN10A (0.56) SCN8ASCN10A
SCHEMBL23027368 0.87 SCN8A (0.56) SCN8ASCN10A
SCHEMBL23027452 0.87 SCN10A (0.55) SCN8ASCN10A
SCHEMBL22203163 0.86 SCN8A (0.42) SCN8ASCN10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021032074-A1 BENZAMIDE FUSED AROMATIC RING DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN MEDICINE 江苏恒瑞医药股份有限公司 2021-02-25 WO disclosed