Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TACR2 | P21452 | 1/20 | 0.30 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2271357 | 0.96 | PIK3CD (0.42) | PIK3CDPIK3CAPIK3CBPIK3CGHRH3 | |
| SCHEMBL2270429 | 0.88 | PIK3CD (0.44) | PIK3CDPIK3CAPIK3CBPIK3CGHRH3 | |
| SCHEMBL2357042 | 0.83 | PIK3CD (0.42) | PIK3CDPIK3CAPIK3CBPIK3CGHRH3 | |
| SCHEMBL2277063 | 0.82 | PIK3CD (0.40) | PIK3CDPIK3CAPIK3CBPIK3CGHRH3 | |
| SCHEMBL2272865 | 0.82 | SMN1; SMN2 (0.44) | PIK3CDPIK3CAPIK3CGSMN1; SMN2KDM4E | |
| SCHEMBL2271455 | 0.79 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGHRH3 | |
| SCHEMBL2277020 | 0.77 | PIK3CD (0.45) | PIK3CDPIK3CAPIK3CBPIK3CGHRH3 | |
| SCHEMBL2276355 | 0.77 | PIK3CD (0.40) | PIK3CDPIK3CAPIK3CBPIK3CGHRH3 | |
| SCHEMBL2269670 | 0.76 | PIK3CD (0.76) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2273572 | 0.75 | PIK3CD (0.45) | PIK3CDPIK3CAPIK3CBPIK3CGCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101429-A1 | PYRIDO[3,2-D]PYRIMIDINE PI3K DELTA INHIBITOR COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-25 | — | — | WO | disclosed |