Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2272862 | 0.86 | SMN1; SMN2 (0.41) | PIK3CDCYP11B2TSHRPIK3CAPIK3CG | |
| SCHEMBL2303371 | 0.86 | PIK3CD (0.39) | PIK3CDCYP11B2TSHRPIK3CAPIK3CG | |
| SCHEMBL2275207 | 0.83 | PIK3CD (0.39) | PIK3CDCYP11B2TSHRPIK3CAPIK3CG | |
| SCHEMBL2274088 | 0.83 | PIK3CA (0.41) | PIK3CDPIK3CAPIK3CGPIK3CBSMN1; SMN2 | |
| SCHEMBL2268269 | 0.80 | PIK3CD (0.42) | PIK3CDPIK3CAPIK3CGPIK3CBSMN1; SMN2 | |
| SCHEMBL2270052 | 0.79 | PIK3CA (0.43) | PIK3CDPIK3CAPIK3CGSMN1; SMN2KDM4E | |
| SCHEMBL2305471 | 0.78 | PIK3CD (0.34) | PIK3CDCYP11B2TSHRPIK3CAPIK3CG | |
| SCHEMBL2271455 | 0.76 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CGPIK3CBSMN1; SMN2 | |
| SCHEMBL2275660 | 0.75 | PIK3CD (0.53) | PIK3CDPIK3CAPIK3CGSMN1; SMN2KDM4E | |
| SCHEMBL12370236 | 0.75 | SMN1; SMN2 (0.47) | PIK3CDPIK3CAPIK3CGSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539337-A1 | PYRIDO[3,2-D]PYRIMIDINE PI3K DELTA INHIBITOR COMPOUNDS AND METHODS OF USE | F. Hoffmann-La Roche AG (CH) | 2013-01-02 | — | — | EP | disclosed |
| WO-2011101429-A1 | PYRIDO[3,2-D]PYRIMIDINE PI3K DELTA INHIBITOR COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-25 | — | — | WO | disclosed |