Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 5/20 | 0.48 |
| ▸ | KIT | P10721 | 5/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 5/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23035014 | 0.91 | PRMT5 (0.51) | PRMT5KITBTKTBK1EIF2AK2 | |
| SCHEMBL29538307 | 0.91 | PRMT5 (0.51) | PRMT5KITBTKTBK1EIF2AK2 | |
| SCHEMBL21484302 | 0.86 | PRMT5 (0.43) | PRMT5KITBTKTBK1EGFR | |
| SCHEMBL21484347 | 0.82 | KDR (0.40) | PRMT5KITEIF2AK2GSK3BEGFR | |
| SCHEMBL21484381 | 0.79 | PRMT5 (0.47) | PRMT5KITBTKTBK1EIF2AK2 | |
| SCHEMBL21484369 | 0.79 | KIT (0.33) | KITBTKEGFRERBB2FLT3 | |
| SCHEMBL21484374 | 0.78 | ERBB2 (0.61) | BTKEGFRERBB2FLT3 | |
| SCHEMBL21484380 | 0.78 | KIT (0.48) | PRMT5KITBTKEIF2AK2GSK3B | |
| SCHEMBL21484329 | 0.77 | ERBB2 (0.47) | PRMT5BTKEIF2AK2GSK3BEGFR | |
| SCHEMBL21484304 | 0.77 | PRMT5 (0.46) | PRMT5KITBTKTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3556761-B1 | PYRROLO-AROMATIC HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF | THE NATIONAL INSTITUTES OF PHARMACEUTICAL RES AND DEVELOPMENT NIP (CN) | 2021-03-03 | — | — | EP | claimed |