Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.71 |
| ▸ | PLK1 | P53350 | 1/20 | 0.71 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.59 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.59 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.59 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.59 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.59 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.59 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.59 |
| ▸ | MGAM | O43451 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | SI | P14410 | 1/20 | 0.56 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.56 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.53 |
| ▸ | TUBB | P07437 | 1/20 | 0.53 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.53 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.53 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.53 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.53 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1300789 | 1.00 | PLK4 (0.71) | PLK4PLK1LRRK2PSEN1PSEN2 | |
| SCHEMBL250593 | 0.90 | LRRK2 (0.65) | PLK4PLK1LRRK2PSEN1PSEN2 | |
| SCHEMBL29443853 | 0.90 | LRRK2 (0.65) | PLK4PLK1LRRK2PSEN1PSEN2 | |
| SCHEMBL8205160 | 0.90 | LRRK2 (0.65) | PLK4PLK1LRRK2PSEN1PSEN2 | |
| SCHEMBL250592 | 0.90 | LRRK2 (0.65) | PLK4PLK1LRRK2PSEN1PSEN2 | |
| SCHEMBL5477775 | 0.90 | LRRK2 (0.74) | PLK4PLK1LRRK2PSEN1PSEN2 | |
| SCHEMBL1300824 | 0.90 | LRRK2 (0.74) | PLK4PLK1LRRK2PSEN1PSEN2 | |
| SCHEMBL2132052 | 0.85 | LRRK2 (0.78) | PLK4PLK1LRRK2PSEN1PSEN2 | |
| SCHEMBL1021458 | 0.85 | LRRK2 (0.78) | PLK4PLK1LRRK2PSEN1PSEN2 | |
| SCHEMBL1021460 | 0.85 | LRRK2 (0.78) | PLK4PLK1LRRK2PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350001-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | National University of Singapore (SG) | 2011-08-03 | — | — | EP | claimed |
| WO-2010044753-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2010-04-22 | — | — | WO | claimed |