SCHEMBL23042226

SCHEMBL23042226

O=C(OCc1cc[c]cc1)Oc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.67

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.67
BCL9 O00512 1/20 0.47
CTNNB1 P35222 1/20 0.47
MAOB P27338 1/20 0.46
GAA P10253 2/20 0.46
AKR1C3 P42330 1/20 0.46
RAB9A P51151 1/20 0.44
IDO1 P14902 2/20 0.43
ALDH1A1 P00352 1/20 0.43
MAPK1 P28482 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
PKM P14618 1/20 0.43
KMT2A Q03164 1/20 0.43
PLA2G4B P0C869 1/20 0.42
MGLL Q99685 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10490876 0.94 HTR2A (0.67) HTR2ABCL9CTNNB1MAOBGAA
SCHEMBL5827968 0.90 HTR2A (0.80) HTR2ABCL9CTNNB1MAOBGAA
SCHEMBL1714950 0.86 HTR2A (0.70) HTR2ABCL9CTNNB1RAB9AALDH1A1
SCHEMBL14621621 0.86 HTR2A (0.74) HTR2ABCL9CTNNB1MAOBGAA
Water SCHEMBL10938437 0.85 HTR2A (0.73) HTR2ABCL9CTNNB1MAOBGAA
Water SCHEMBL10938430 0.85 HTR2A (0.73) HTR2ABCL9CTNNB1MAOBGAA
SCHEMBL6594172 0.83 HTR2A (0.74) HTR2ABCL9CTNNB1MAOBGAA
SCHEMBL20480867 0.83 HTR2A (0.70) HTR2ABCL9CTNNB1MAOBGAA
SCHEMBL4112112 0.83 HTR2A (0.74) HTR2ABCL9CTNNB1MAOBGAA
SCHEMBL25187205 0.83 HTR2A (0.70) HTR2ABCL9CTNNB1MAOBGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4021916-A1 4'-ETHYNYL-2'-DEOXYADENOSINE DERIVATIVES AND THEIR USE IN HIV THERAPY GlaxoSmithKline Intellectual Property (No. 2) Limited (GB) 2022-07-06 EP disclosed
WO-2021038509-A1 4'-ETHYNYL-2'-DEOXYADENOSINE DERIVATIVES AND THEIR USE IN HIV THERAPY GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2021-03-04 WO disclosed