Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 16/20 | 0.80 |
| ▸ | MAP4K2 | Q12851 | 16/20 | 0.80 |
| ▸ | ABL1 | P00519 | 2/20 | 0.73 |
| ▸ | BMX | P51813 | 2/20 | 0.73 |
| ▸ | BCR | P11274 | 1/20 | 0.73 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.73 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.73 |
| ▸ | LCK | P06239 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19922745 | 0.90 | TNK2 (0.84) | TNK2MAP4K2ABL1BMXBCR | |
| SCHEMBL23059372 | 0.89 | TNK2 (0.79) | TNK2MAP4K2ABL1BMXBCR | |
| SCHEMBL19922743 | 0.88 | TNK2 (0.73) | TNK2MAP4K2ABL1BMXBCR | |
| SCHEMBL19922758 | 0.88 | TNK2 (0.78) | TNK2MAP4K2ABL1BMXBCR | |
| SCHEMBL19865443 | 0.87 | TNK2 (0.72) | TNK2MAP4K2ABL1BMXBCR | |
| SCHEMBL19922946 | 0.86 | TNK2 (0.73) | TNK2MAP4K2ABL1BMXBCR | |
| SCHEMBL23648637 | 0.86 | TNK2 (0.70) | TNK2MAP4K2ABL1BMXBCR | |
| SCHEMBL23045858 | 0.86 | TNK2 (0.82) | TNK2MAP4K2ABL1BMXBCR | |
| SCHEMBL19922940 | 0.86 | TNK2 (0.84) | TNK2MAP4K2ABL1BMXBCR | |
| SCHEMBL23666351 | 0.86 | TNK2 (0.70) | TNK2MAP4K2ABL1BMXBCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021040422-A1 | NOVEL PYRIMIDO[4,5-D]PYRIMIDINE-2-ONE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY | 한국과학기술연구원 | 2021-03-04 | — | — | WO | claimed |
| WO-2021040422-A1 | NOVEL PYRIMIDO[4,5-D]PYRIMIDINE-2-ONE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY | 한국과학기술연구원 | 2021-03-04 | — | — | WO | disclosed |