Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 7/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21397614 | 0.87 | KDM1A (0.56) | KDM1AHDAC1HDAC6KEAP1NFE2L2 | |
| SCHEMBL21851881 | 0.73 | KDM1A (0.53) | KDM1AHDAC1HDAC6OPRD1OPRK1 | |
| SCHEMBL7885006 | 0.73 | KDM1A (0.59) | KDM1AHDAC1HDAC6OPRD1OPRK1 | |
| SCHEMBL7886359 | 0.73 | KDM1A (0.59) | KDM1AHDAC1HDAC6OPRD1OPRK1 | |
| SCHEMBL7882072 | 0.73 | KDM1A (0.59) | KDM1AHDAC1HDAC6OPRD1OPRK1 | |
| SCHEMBL14272807 | 0.72 | KDM1A (0.57) | KDM1AHDAC1HDAC6NAMPTHDAC8 | |
| SCHEMBL18838379 | 0.70 | STS (0.51) | KDM1AKEAP1NFE2L2OPRD1OPRK1 | |
| SCHEMBL22793104 | 0.69 | KDM1A (0.52) | KDM1AHDAC1HDAC6NAMPTHDAC8 | |
| SCHEMBL31096851 | 0.69 | KDM1A (0.52) | KDM1AHDAC1HDAC6NAMPTHDAC8 | |
| SCHEMBL29771047 | 0.69 | KDM1A (0.52) | KDM1AHDAC1HDAC6NAMPTHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10934302-B1 | SHP2 phosphatase inhibitors and methods of use thereof | RELAY THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934302-B1 | SHP2 phosphatase inhibitors and methods of use thereof | PTPRCAP, PTPRJ, PTPRC | KDM1A 1283/4885HDAC1 657/4885HDAC6 431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.