Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 20/20 | 0.54 |
| ▸ | NTRK3 | Q16288 | 10/20 | 0.54 |
| ▸ | NTRK2 | Q16620 | 8/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23047208 | 1.00 | NTRK1 (0.54) | NTRK1NTRK3NTRK2 | |
| SCHEMBL18376031 | 0.93 | NTRK1 (0.50) | NTRK1NTRK3NTRK2 | |
| SCHEMBL20359535 | 0.93 | NTRK1 (0.50) | NTRK1NTRK3NTRK2 | |
| SCHEMBL20359533 | 0.93 | NTRK1 (0.50) | NTRK1NTRK3NTRK2 | |
| SCHEMBL29497147 | 0.91 | NTRK1 (0.51) | NTRK1NTRK3NTRK2 | |
| SCHEMBL23037392 | 0.88 | NTRK1 (0.59) | NTRK1NTRK3NTRK2 | |
| SCHEMBL23037390 | 0.88 | NTRK1 (0.59) | NTRK1NTRK3NTRK2 | |
| SCHEMBL31171166 | 0.88 | NTRK1 (0.59) | NTRK1NTRK3NTRK2 | |
| SCHEMBL18376029 | 0.87 | NTRK1 (0.45) | NTRK1NTRK3NTRK2 | |
| SCHEMBL20359268 | 0.87 | NTRK1 (0.45) | NTRK1NTRK3NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3786167-A1 | DIARYL MACROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION, AND USE THEREOF | Primegene (Beijing) Co., Ltd. (CN) | 2021-03-03 | — | — | EP | disclosed |