Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.48 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.46 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.41 |
| ▸ | CDK9 | P50750 | 8/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26551345 | 0.90 | GCK (0.43) | EHMT2 | |
| SCHEMBL21081132 | 0.79 | HTR2C (0.50) | HTR2CHTR2AHTR1ASLC6A2SLC6A4 | |
| SCHEMBL29752771 | 0.79 | HTR2C (0.50) | HTR2CHTR2AHTR1ASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL30440116 | 0.78 | HTR2C (0.51) | HTR2CHTR2AHTR1ASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL21045693 | 0.78 | HTR2C (0.51) | HTR2CHTR2AHTR1ASLC6A2SLC6A4 | |
| SCHEMBL23426724 | 0.76 | HTR2C (0.47) | HTR2CHTR2AHTR1ASLC6A2SLC6A4 | |
| SCHEMBL24610451 | 0.76 | HTR2C (0.47) | HTR2CHTR2AHTR1ASLC6A2SLC6A4 | |
| SCHEMBL23047426 | 0.75 | HTR2C (0.42) | HTR2CEHMT2EHMT1HTR2AHTR1A | |
| SCHEMBL24610471 | 0.75 | GCK (0.38) | CCNT1CDK9CHEK1 | |
| SCHEMBL26548534 | 0.74 | PDE10A (0.45) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3786160-B1 | PYRIDINE DERIVATIVES AND THERAPEUTIC USES THEREOF AS TRPC6 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2022-07-13 | — | — | EP | disclosed |
| EP-3786160-A1 | PYRIDINE DERIVATIVES AND THERAPEUTIC USES THEREOF AS TRPC6 INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2021-03-03 | — | — | EP | disclosed |