Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 19/20 | 0.65 |
| ▸ | WNT1 | P04628 | 13/20 | 0.65 |
| ▸ | GSK3B | P49841 | 11/20 | 0.65 |
| ▸ | CLK2 | P49760 | 4/20 | 0.48 |
| ▸ | CLK3 | P49761 | 4/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23048900 | 0.83 | DYRK1A (0.66) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL23048702 | 0.83 | DYRK1A (0.64) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL23916295 | 0.82 | DYRK1A (0.67) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL23916587 | 0.81 | DYRK1A (0.63) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL23048703 | 0.80 | DYRK1A (0.64) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL23916141 | 0.79 | DYRK1A (0.63) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL19516990 | 0.79 | DYRK1A (1.00) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL23048650 | 0.78 | DYRK1A (0.61) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL19546937 | 0.77 | DYRK1A (0.67) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL23916556 | 0.77 | DYRK1A (0.75) | DYRK1AWNT1GSK3BCLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3448386-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | SAMUMED LLC (US) | 2021-03-03 | — | — | EP | disclosed |