Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 20/20 | 0.60 |
| ▸ | GSK3B | P49841 | 14/20 | 0.60 |
| ▸ | WNT1 | P04628 | 13/20 | 0.60 |
| ▸ | CLK2 | P49760 | 7/20 | 0.57 |
| ▸ | CLK3 | P49761 | 7/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23916637 | 0.92 | DYRK1A (0.62) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL19540269 | 0.79 | DYRK1A (0.73) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23048578 | 0.76 | DYRK1A (0.81) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916244 | 0.76 | DYRK1A (0.61) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916670 | 0.76 | GSK3B (0.56) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916144 | 0.76 | DYRK1A (0.61) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916423 | 0.76 | DYRK1A (0.82) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL19540227 | 0.76 | DYRK1A (0.72) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL19516400 | 0.75 | DYRK1A (1.00) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL32665204 | 0.75 | DYRK1A (1.00) | DYRK1AGSK3BWNT1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3448386-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | SAMUMED LLC (US) | 2021-03-03 | — | — | EP | disclosed |