Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 20/20 | 0.61 |
| ▸ | GSK3B | P49841 | 15/20 | 0.61 |
| ▸ | WNT1 | P04628 | 9/20 | 0.61 |
| ▸ | CLK2 | P49760 | 3/20 | 0.57 |
| ▸ | CLK3 | P49761 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19546539 | 0.92 | DYRK1A (0.72) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL19546567 | 0.83 | GSK3B (0.67) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL30695495 | 0.81 | PIK3CD (0.55) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL24219436 | 0.79 | DYRK1A (0.65) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL19546538 | 0.77 | TTK (0.55) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL24219575 | 0.77 | GSK3B (0.62) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL24219199 | 0.77 | GSK3B (0.52) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL30006387 | 0.77 | GSK3B (1.00) | DYRK1AGSK3BWNT1 | |
| SCHEMBL24219130 | 0.77 | DYRK1A (0.79) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL19515954 | 0.77 | GSK3B (1.00) | DYRK1AGSK3BWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3943086-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | BioSplice Therapeutics, Inc. (US) | 2022-01-26 | — | — | EP | disclosed |
| EP-3448838-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | BIOSPLICE THERAPEUTICS INC (US) | 2021-08-11 | — | — | EP | disclosed |
| EP-3448386-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | SAMUMED LLC (US) | 2021-03-03 | — | — | EP | disclosed |