Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 20/20 | 0.82 |
| ▸ | WNT1 | P04628 | 19/20 | 0.56 |
| ▸ | GSK3B | P49841 | 15/20 | 0.56 |
| ▸ | CLK2 | P49760 | 3/20 | 0.51 |
| ▸ | CLK3 | P49761 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23048863 | 0.90 | DYRK1A (0.89) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL19546583 | 0.90 | DYRK1A (0.89) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL19516319 | 0.90 | DYRK1A (1.00) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL19540157 | 0.86 | DYRK1A (0.82) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL19537575 | 0.82 | DYRK1A (0.75) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL23048876 | 0.80 | DYRK1A (0.65) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL20948689 | 0.78 | DYRK1A (0.78) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL20948305 | 0.78 | DYRK1A (0.78) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL23048592 | 0.77 | DYRK1A (0.83) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL19540158 | 0.77 | DYRK1A (0.72) | DYRK1AWNT1GSK3BCLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3448386-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | SAMUMED LLC (US) | 2021-03-03 | — | — | EP | disclosed |