Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2307327 | 0.84 | HIF1A (0.46) | HIF1ARAB9ATSHRRIPK1ALDH1A1 | |
| SCHEMBL2307011 | 0.80 | HSP90AB1 (0.44) | LMNAHIF1ARAB9ATSHRRIPK1 | |
| SCHEMBL2310120 | 0.78 | HIF1A (0.61) | CYP1A2LMNAHIF1ASMN1; SMN2KDM4E | |
| SCHEMBL4243185 | 0.77 | KDM4E (0.47) | CYP1A2LMNAHIF1ATSHRSMN1; SMN2 | |
| SCHEMBL24571662 | 0.73 | CTSA (0.49) | CYP1A2SMN1; SMN2RIPK1KDM4EMAPK1 | |
| SCHEMBL7451835 | 0.71 | GRM4 (0.50) | CYP1A2SMN1; SMN2RIPK1KDM4EDYRK1A | |
| SCHEMBL14355563 | 0.70 | KDM4E (0.61) | LMNANPC1RAB9ATSHRSMN1; SMN2 | |
| SCHEMBL7451831 | 0.69 | KDM4E (0.46) | CYP1A2NPC1RAB9ATSHRSMN1; SMN2 | |
| SCHEMBL19531976 | 0.69 | BRD4 (0.51) | CYP1A2LMNASMN1; SMN2RIPK1KDM4E | |
| SCHEMBL8101444 | 0.69 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2RIPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350077-A1 | FUSED, SPIROCYCLIC HETEROAROMATIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | AstraZeneca AB (SE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043893-A1 | FUSED, SPIROCYCLIC HETEROAROMATIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2010-04-22 | — | — | WO | disclosed |