Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRNP | P04156 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 6/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.49 |
| ▸ | AURKA | O14965 | 4/20 | 0.49 |
| ▸ | MET | P08581 | 4/20 | 0.49 |
| ▸ | TEK | Q02763 | 4/20 | 0.49 |
| ▸ | SRC | P12931 | 3/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.48 |
| ▸ | RET | P07949 | 5/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2210933 | 0.87 | RET (0.63) | PRNPPOLBRECQLMAPTKDR | |
| SCHEMBL2207894 | 0.82 | MAPT (0.65) | PRNPPOLBRECQLMAPTKDR | |
| SCHEMBL6004924 | 0.76 | KDR (0.57) | KDRAURKBAURKAMETTEK | |
| SCHEMBL31218163 | 0.75 | KDR (0.71) | KDRAURKBAURKAMETTEK | |
| SCHEMBL2207029 | 0.75 | FGFR2 (0.72) | MAPTKDRPDGFRBPDGFRAAXL | |
| SCHEMBL29079695 | 0.74 | KDR (0.60) | KDRAURKBAURKAMETTEK | |
| SCHEMBL14047121 | 0.74 | FGFR2 (0.62) | MAPTKDRAURKBAURKARET | |
| SCHEMBL6005288 | 0.73 | KDR (0.52) | KDRAURKBAURKAMETTEK | |
| SCHEMBL2208900 | 0.73 | FGFR2 (0.63) | MAPTKDRAURKBAURKAPDGFRA | |
| SCHEMBL4002749 | 0.72 | KDR (0.61) | KDRAURKBAURKAMETTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981891-B2 | Aurora kinase modulators and method of use | AMGEN INC. (US) | 2011-07-19 | — | — | US | claimed |