Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 5/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23051564 | 0.88 | NR1H2 (0.36) | USP30KDM1APDE4APDE4BPDE4C | |
| SCHEMBL20456330 | 0.80 | KDM1A (0.43) | USP30KDM1APDE4APDE4BPDE4C | |
| SCHEMBL21943246 | 0.80 | HDAC1 (0.42) | USP30KDM1APDE4APDE4BPDE4C | |
| SCHEMBL19839783 | 0.78 | KDM1A (0.42) | USP30KDM1APDE4APDE4BPDE4C | |
| SCHEMBL25232243 | 0.78 | KDM1A (0.41) | USP30KDM1APDE4APDE4BPDE4C | |
| SCHEMBL21408126 | 0.78 | KDM1A (0.41) | USP30KDM1APDE4APDE4BPDE4C | |
| SCHEMBL25281708 | 0.76 | KDM1A (0.40) | USP30KDM1APDE4APDE4BPDE4C | |
| SCHEMBL15872132 | 0.76 | BACE1 (0.39) | USP30KDM1AESR2NR1H2BUB1 | |
| SCHEMBL29348862 | 0.75 | USP2 (0.41) | USP30KDM1APDE4APDE4BPDE4C | |
| SCHEMBL17113437 | 0.74 | KDM1A (0.39) | USP30KDM1APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021041664-A1 | CEREBLON E3 LIGASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-03-04 | — | — | WO | disclosed |