SCHEMBL23057749

SCHEMBL23057749

CCc1nc(N)c2c(-c3ccc(NC(=O)C(O)c4cccc(F)c4)cc3C)cn(C)c2n1

nearest known ligand 0.47

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EIF2AK3 Q9NZJ5 19/20 0.47
EIF2S1 P05198 18/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30060890 1.00 EIF2AK3 (0.47) EIF2AK3EIF2S1
SCHEMBL29683858 0.90 EIF2AK3 (0.49) EIF2AK3EIF2S1
SCHEMBL29684207 0.90 EIF2AK3 (0.49) EIF2AK3EIF2S1
SCHEMBL23043901 0.90 EIF2AK3 (0.49) EIF2AK3EIF2S1
SCHEMBL23043875 0.90 EIF2AK3 (0.49) EIF2AK3EIF2S1
SCHEMBL29684160 0.90 EIF2AK3 (0.49) EIF2AK3EIF2S1
SCHEMBL23043873 0.90 EIF2AK3 (0.49) EIF2AK3EIF2S1
SCHEMBL23043978 0.88 EIF2AK3 (0.47) EIF2AK3EIF2S1
SCHEMBL23043975 0.88 EIF2AK3 (0.47) EIF2AK3EIF2S1
SCHEMBL23044007 0.88 EIF2AK3 (0.47) EIF2AK3EIF2S1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021041975-A1 PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS HIBERCELL, INC. (US) 2021-03-04 WO disclosed