Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 15/20 | 0.55 |
| ▸ | EIF2S1 | P05198 | 9/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30060899 | 1.00 | EIF2AK3 (0.55) | EIF2AK3EIF2S1AURKAIKBKEAURKB | |
| SCHEMBL23044036 | 0.92 | EIF2AK3 (0.53) | EIF2AK3EIF2S1FLT3KITMET | |
| SCHEMBL29746748 | 0.92 | EIF2AK3 (0.53) | EIF2AK3EIF2S1FLT3KITMET | |
| SCHEMBL23044033 | 0.92 | EIF2AK3 (0.53) | EIF2AK3EIF2S1FLT3KITMET | |
| SCHEMBL23044625 | 0.92 | EIF2AK3 (0.53) | EIF2AK3EIF2S1FLT3KITMET | |
| SCHEMBL29684516 | 0.92 | EIF2AK3 (0.53) | EIF2AK3EIF2S1FLT3KITMET | |
| SCHEMBL29683975 | 0.92 | EIF2AK3 (0.53) | EIF2AK3EIF2S1FLT3KITMET | |
| SCHEMBL20541871 | 0.91 | EIF2AK3 (0.51) | EIF2AK3EIF2S1METAXL | |
| SCHEMBL20541872 | 0.91 | EIF2AK3 (0.51) | EIF2AK3EIF2S1METAXL | |
| SCHEMBL23057557 | 0.91 | EIF2AK3 (0.56) | EIF2AK3EIF2S1FLT3KITKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021041975-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | HIBERCELL, INC. (US) | 2021-03-04 | — | — | WO | disclosed |