Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Everolimus. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A known ✓ | P62942 | 9/20 | 0.87 |
| ▸ | MTOR | P42345 | 7/20 | 1.00 |
| ▸ | ABCC3 | O15438 | 2/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 2/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | ABCC2 | Q92887 | 2/20 | 1.00 |
| ▸ | RPTOR | Q8N122 | 2/20 | 1.00 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 1.00 |
| ▸ | KCNE1 | P15382 | 1/20 | 1.00 |
| ▸ | KCNQ1 | P51787 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 0.87 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.87 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Everolimus SCHEMBL22813561 | 1.00 | MTOR (1.00) | MTORABCC3ABCC4ABCB11ABCC2 | |
| Everolimus SCHEMBL23251030 | 1.00 | MTOR (1.00) | MTORABCC3ABCC4ABCB11ABCC2 | |
| Everolimus SCHEMBL20759396 | 1.00 | MTOR (1.00) | MTORABCC3ABCC4ABCB11ABCC2 | |
| Everolimus SCHEMBL25481687 | 1.00 | MTOR (1.00) | MTORABCC3ABCC4ABCB11ABCC2 | |
| Everolimus SCHEMBL23552755 | 1.00 | MTOR (1.00) | MTORABCC3ABCC4ABCB11ABCC2 | |
| Everolimus SCHEMBL23251039 | 1.00 | MTOR (1.00) | MTORABCC3ABCC4ABCB11ABCC2 | |
| Everolimus SCHEMBL24472605 | 1.00 | MTOR (1.00) | MTORABCC3ABCC4ABCB11ABCC2 | |
| Everolimus SCHEMBL23747774 | 1.00 | MTOR (1.00) | MTORABCC3ABCC4ABCB11ABCC2 | |
| Everolimus SCHEMBL22882345 | 1.00 | MTOR (1.00) | MTORABCC3ABCC4ABCB11ABCC2 | |
| Everolimus SCHEMBL21091316 | 1.00 | MTOR (1.00) | MTORABCC3ABCC4ABCB11ABCC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3788369-A1 | BIOMARKERS FOR EVALUATING CAR-T CELLS TO PREDICT CLINICAL OUTCOME | NOVARTIS AG (CH) | 2021-03-10 | — | — | EP | disclosed |